Washington/ISLAMABAD - President Joe Biden said Monday that a U.S. missile strike over the weekend has killed the leader of al-Qaida, Ayman al-Zawahiri, one of the world's most wanted terrorists.
For the past decade, al-Zawahiri headed al-Qaida, the Islamist terror group that spawned franchises around the world after the stunning attacks on U.S. soil on September 11, 2001.
'Now, justice has been delivered,' Biden said Monday night. 'And this terrorist leader is no more.' He added: 'We make it clear again tonight that no matter how long it takes, no matter where you hide, if you are a threat to our people, the United States will find you and take you out.'
The U.S. invaded Afghanistan shortly after the September 11 attacks, and al-Qaida leader Osama bin Laden was the prime target. U.S. forces killed him in Pakistan in 2011.
President Joe Biden speaks from the Blue Room Balcony of the White House, Aug. 1, 2022.
Al-Zawahiri, born in Egypt to a wealthy family and trained as a surgeon, took over the terror group in 2011. Before that, he was said to be bin Laden's personal doctor.
The confirmation of his death came more than an hour after the Taliban rulers in Kabul said a missile attack on Sunday against a residential compound in the Afghan capital was the work of an American drone.
Senior White House officials told reporters Monday night that the operation targeted a house in Kabul with an unmanned aerial vehicle, with no U.S. personnel on the ground. Administration officials also said they concluded with 'high confidence' that only al-Zawahiri was killed, and that they were aware that senior members of the Taliban's Haqqani network knew he was in Afghanistan. Officials said they did not alert the Taliban ahead of the strike.
A senior administration official said al-Zawahiri 'continued to provide strategic direction to al-Qaida affiliates worldwide, calling for attacks on the United States.'
WATCH: Biden Delivers Remarks on Counterterrorism Operation
The Taliban were quick to share their ire.
'The Islamic Emirate of Afghanistan strongly condemns this attack on whatever the pretext,' Taliban spokesman Zabihullah Mujahid said in a statement, using the official name for the Taliban government.
He denounced the strike as a 'blatant violation of international principles and the Doha agreement,' referring to the 2020 talks that Taliban leaders held with the U.S. and Western leaders in Qatar over the withdrawal of U.S. and allied troops the subsequent year.
The Taliban took control of Afghanistan on August 15 as the U.S.-led foreign troops withdrew and the Western-backed government in Kabul as well as its security forces collapsed in the face of the stunning nationwide Taliban assault.
U.S. officials have been in contact with Pakistani leaders to seek an 'over-the-horizon' facility to conduct counterterrorism operations in landlocked Afghanistan after American troops left the country and the Taliban took over.
The U.S.-led military coalition invaded Afghanistan in October 2001 and dislodged the then-Taliban government in Kabul to punish it for harboring the al-Qaida terror network. Bin Laden and al-Zawahiri escaped the international military action.
The U.S.-Taliban agreement also required the Islamist group not to allow any terrorist organization, including al-Qaida, to pose a threat to the security of the United States and other countries from Afghan soil.
But recent United Nations assessments suggested that al-Qaida, boosted by leadership stability and the Taliban takeover of Afghanistan, appeared to be positioning itself to once again be seen as the world's preeminent terror group and as the greatest long-term threat to the West.
Intelligence shared by United Nations member states and published in a new report earlier this month found al-Qaida was enjoying a degree of freedom under Taliban rule, allowing its leadership to communicate more often and more easily with affiliates and followers. The report further concluded that al-Zawahiri, long rumored to be in ill health or dying, was 'alive and communicating freely.'
Al-Qaida leader Ayman al-Zawahiri, who was killed in a CIA drone strike in Afghanistan over the weekend according to U.S. officials, appears in an undated FBI Most Wanted poster. (FBI/Handout via Reuters)
The U.N. report similarly cautions that while al-Qaida may be better positioned, it is likely to refrain from launching external attacks in order to not embarrass Afghanistan's Taliban rulers and because the al-Qaida core still lacks 'an external operational capability.'
Analyst Bradley Bowman, senior director of the Center on Military and Political Power at the Foundation for Defense of Democracies, said it is important for the U.S. to cut out terror groups at their roots.
'The goal is to keep pressure on terrorists over there so they don't have the ability to kill us here,' he said. 'Every policy decision in Washington should be judged, at least in part, by that metric.'
U.S. Senator Ted Cruz praised the operation.
'This is an important accomplishment,' the Texas senator said in a statement. 'All Americans will breathe easier today knowing Ayman al-Zawahiri, the leader of Al-Qaeda, has been eliminated. This strike should be a message to terrorists near and far: if you conspire to kill Americans, we will find and kill you.'
Biden said the killing could lead to a new era.
'Now we have eliminated the emir of al-Qaida,' he said. 'He will never again - never again - allow Afghanistan to become a terrorist safe haven because he's gone and we're going to make sure that nothing else happens. You know, it can't be a launching pad against the United States. We're going to see to it that won't happen.'
Meanwhile in recent years, al-Qaida has continued to expand, launching violent affiliate groups in the Middle East, West and East Africa, and South Asia.
Jeff Seldin, VOA's national security correspondent, contributed to this report.